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Gut Imbalance & GLP-1.
Patients with gut imbalance may experience a weaker response to GLP-1–based therapies.
Dr. Dave Moreno, M.D. prioritizes his patients individual needs, emphasizes prevention and seeks to restore health rather than just manage disease.
GLP-1 and how it works.
GLP-1, or glucagon-like peptide-1, is a hormone that is naturally produced in the intestines in response to food intake. It is released after eating and is involved in the regulation of blood sugar levels. In the body, the release of insulin is stimulated and the secretion of glucagon is inhibited by GLP-1, resulting in a reduction in blood glucose levels. Additionally, gastric emptying is slowed and a feeling of fullness is promoted, which can contribute to reduced food intake. Because of these effects, GLP-1 has been utilized in the treatment of type 2 diabetes and obesity through medications that mimic or enhance its action.
Why is GLP-1 not effective in some patients?
GLP-1 may not be effective in some patients due to a variety of factors that influence individual response. In some cases, the body’s receptors for GLP-1 may become less sensitive or downregulated, reducing the hormone’s ability to exert its effects. Additionally, genetic differences, underlying medical conditions such as severe insulin resistance, or variations in gut hormone signaling can contribute to reduced efficacy. Lifestyle factors, including diet, physical activity, and medication adherence, also play a role. Furthermore, in some individuals, the GLP-1 pathway may already be impaired, limiting the potential benefit of GLP-1–based therapies.
How does gut imbalance effect how GLP-1 works in patients.
Gut imbalance, often referred to as gut dysbiosis, can significantly affect how GLP-1 works in patients. When the composition of gut microbiota is disrupted, the production and signaling of GLP-1 can be altered. Certain beneficial bacteria are known to stimulate the release of GLP-1 by fermenting dietary fibers into short-chain fatty acids, which activate receptors on intestinal L-cells. In dysbiosis, this process may be impaired, leading to reduced GLP-1 secretion. Additionally, inflammation and increased intestinal permeability associated with an imbalanced gut may interfere with GLP-1 receptor function and insulin sensitivity, further diminishing the hormone’s effectiveness. As a result, patients with gut imbalance may experience a weaker response to GLP-1–based therapies.
Board-Certified in Internal Medicine and Nutrition
How do you know if you have a gut imbalance?
And how do we repair gut imbalance.
At New Age Medical Centers, we repair Gut imbalance through a combination of dietary adjustments, lifestyle changes, and targeted supplementation. A nutrient-rich diet that includes fiber, fermented foods, and probiotics is often recommended to restore beneficial bacteria and promote a healthy microbiome. The reduction of processed foods, excessive sugar, and artificial additives helps to minimize inflammation and further disruption. If an underlying condition or infection is present, medical guidance may be necessary to address the root cause effectively. Continue Reading >>
New Age Medical Center
We offer services such as internal medicine, anti-aging, nutritional & weight loss programs, nutraceuticals, hormone therapy and a holistic approach to treating fibromyalgia, chronic fatigue, leaky gut, diabetes, cardio-metabolic syndrome and chronic illness.
APPOINTMENTS: (352) 596-9095 or (813) 528-4064 • MOBILE: (352) 263-5447 • FAX: (352) 578-1032
Brooksville Location Office
Mon-Wed: 9 AM to 5 PM • Thu-Fri: 9 AM to 2 PM
Land O’ Lakes Office
Thu-Fri: 3 PM to 7 PM
